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Human Male Sex: Endocrine Disruption and Male Reproductive Wellness

Human Male Sex: Endocrine Disruption and Male Reproductive Wellness

9.1 Introduction

Male sexuality is decided genetically during the time of fertilization by the existence of a Y chromosome within the spermatozoan since it fuses because of the X-chromosome-containing ovum, while the region that is sex-determining of Y chromosome (SRY) then drives the bipotential gonad for the embryo in order to become a testis through hormone-independent mechanisms 1,2. Nevertheless, after the testis that is early created, growth of the total male phenotype, including further testicular development (masculinization), becomes totally determined by a complex community of hormonal signals, especially hormones secreted through the testes 2. People who lack any gonads are phenotypically female 1 and endocrine intervention is needed to modify the standard feminine phenotype in order to become male 2.

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